Prediction of Outcome in Patients with Guillain Barre Syndrome

Abstract

 Guillain-Barre syndrome (GBS) is an acute-onset, monophasic immune-mediated disorder of the peripheral nervous system that often follows an antecedent infection  In this study the study population included twenty patients with the diagnosis of Guillain Barre Syndrome within two weeks from onset of neurologic symptoms, whom their diagnosis based on the established clinical criteria and verified by investigations. Patients were selected from both genders and aged from 18 to 65 years old. Nerve conduction studies and electromyography were performed within two week from admission. In this study various lines of treatment such as plasma exchange, IVIG or both were received during the period of admission in hospital.  In this study, Guillain-Barre syndrome had a male preponderance with older age groups more commonly affected older age groups is a predictor of poor outcome.  An antecedent infection was seen in all cases as gastroenteritis and respiratory tract infection while the majority of patients had respiratory tract infection.  Ascending pattern of weakness is more common than descending pattern in this study population and not related to prognosis