Effect OF Sildenafil Citrate on Peripheral Natural Killer Cells in women with Recurrent Pregnancy Loss (A Clinical Trial)

Abstract

esearchers defined recurrent miscarriage as three or more pregnancy losses, the available research data denotes that the risk of abortion is 30% and 33% after two miscarriages and three miscarriages, consecutively. Correspondingly the up-to-date guidelines by the American Society for Reproductive Medicine define recurrent pregnancy loss as two or more pregnancy losses, which have been confirmed by either ultrasound or histopathological study. Research studies furthermore classify recurrent pregnancy loss as primary or secondary. Primary recurrent pregnancy loss cases have never reached viability, while in the secondary type, live birth have occurred at some time. On the other hand, there is no particular terminology given to multiple spontaneous miscarriage interposed with normal gestation. It is crucial to perform an early assessment in clinical scenarios where fetal cardiac activity have been documented before the loss, in women who are older than 35 years and/or in couples with clinical infertility history. Incidence of Recurrent pregnancy loss affects around 0.4–1% of couples. The clinical risk of losing the gestation is more in early pregnancies, frequently in the first gestational trimester. There is about 22–57% miscarriage risk with pregnancy less than 6 weeks.