Correlation Between Serum Level Of Immunoglobulin And Antiepileptic Drugs In Sample Of Egyptian Epileptic Patients

Abstract

This clinical study was conducted to verify serum concentration of immunoglobulin; IgG, IgA and IgM in patients with focal epilepsy treated with three different antiepileptic drugs carbamazepine (CBZ), Sodium valproate (VPA) and Levetiracetam (LEV) as monotherapy and as polytherapy. This clinical study was conducted at Epilepsy clinic of Ain Shams University hospitals, Cairo, Egypt, 82 patients with focal epilepsy participated in this study and were divided into 5 subgroups: sodium valproate group, carbamazepine group, carbamazepine and sodium valproate group, carbamazepine and levetiracetam group and group without treatment with AEDs. More than 50 million people worldwide have epilepsy, making it one of the most common neurological diseases globally. Nearly 80% of people with epilepsy living in low-and middle income countries. Antiepileptic drugs (AEDs) are the cornerstone in epilepsy treatment. Increasing of evidence indicated that beside the central nervous system, antiepileptic drugs may also affect the immune system. Experimental data showed that classical and newer antiepileptic drugs affect peripheral immunological parameters.