Fatty Liver : Clinical Revisit

Abstract

Fatty liver defined as accumulation of fat, largely triglycerides, exceeding 5o/o of the liver weight. or visualization of more than 5% of hepatocytes containing fatty droplets on light microscopy. The disease is classified to non alcoholic fatty liver disease (NAFLD ) and alcoholic fatty liver disease ( AFLD ) .It is due to failure of normal hepatic fat metabolism either due to defect within the hepatocyte or to delivery of excess fat, fatty acid or carbohydrates beyond the secretory capacity of lipid of the liver cell. Non alcoholic fatty liver diseases (NAFLD) represents a spectrum of several clinicopathologcal entities from simple steatosis to cirrhosis including steatosis alone, steatonecrosis, steatohepatitis and histological alcoholic - like hepatitis. In the general population, the estimated prevelance ranges from 3%-24%, with most estimates in the 6o/o to 14% ranges Alcohol-induced liver disease can be divided into the

following 3 groups: alcoholic fatty liver (simple steatosis), alcoholic hepatitis, and alcohol-related cirrhosis. Alcoholic fatty liver is an early and reversible consequence of excessive alcohol consumption P.tioCogy of (JrJf.P£(/))

I- Standard"(Cfassic) P.tioCogica{ Pactors

(A) Nutritional abnonnalities

(1) Obesity

(2) Total parenteral nutrition

(3) Choline deficiency

(4) Rapid eight loss