Evaluation of Ginger and Monocationic Bithiophene Activity against Dimethylhydrazine-Induced Colon Cancer in Male Albino Rats

Abstract

Cancer is a class of diseases characterized by out-of-control cell growth. Cancer is one of the most important public health burdens in developed and developing counteries. Globally, colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and females. In 2017, as indicated by the American Cancer Society, there was an expected 95,520 new instances of colon malignancy, in which 47,700 were men and 47,820 women. CRCs start in the lining of the bowel and if left untreated, it can grow into muscle layer beneath, and then through bowel wall. The present study aimed to investigate the in vivo and in vitro antioxidant and anticancer activities of ginger extract (GE) and a novel bithiophene (BT) against colorectal cancer and to understand the molecular mechanism(s) through which GE and BT exerts their antiproliferative and anticancer activities. This study also aimed to evaluate the effect of GE or BT on liver and kidney functions.