Effect of Bone Marrow Derived Stem Cells versus Insulin on the Lingual Papillae of Diabetic Albino Rats (Light and Scanning Electron Microscopic Study)

Abstract

DM is a chronic metabolic disorder with high blood glucose levels. Diabetes often leads to serious complications that affect various tissues in the body. Elevated levels of glucose enhance protein glycation with formation of AGEs. The accumulation of AGEs as well as ROS production contributed to diabetic complications. Many studies illustrated that complications associated with DM can be prevented, reduced or even reversed through proper control of blood glucose levels by using exogenous insulin. However, administration of exogenous insulin cannot mimic precise pancreatic beta cell regulation of glucose homeostasis and frequently associated with severe hypoglycaemic episodes.