Comparative study between Microalbuminuria and Simplified Acute Physiology score as a marker of mortality in septic critically ill patients

Abstract

Sepsis remains a major global healthcare concern, owing to high morbidity and mortality, despite the advances in medical therapeutics. Targeted therapies probably lose their efficacy due to late administration. Early administration of intensive therapy to critically ill patients has shown promise in improving mortality. An early event is the loss of barrier integrity leading to systemic capillary leak which is manifested as increased excretion of albumin in the urine. Microalbuminuria, defined as 30–300 mg/day of albumin excretion in the urine is a common finding in critically ill patients, where it has shown promise not only as a predictor of organ failure and vasopressor requirement but of mortality, faring better than SAPS II and APACHE II score.