Molecular Design and Synthesis of Small Organic Molecules as Anticancer Targeting Agents

Abstract

Cancer is a collection of complex diseases. It begins when some of normal body cells start to divide and grow out of control, forming a mass or sheet of cells called tumor. It is a major cause of death throughout the world. According to the American Cancer Society, the number of deaths caused by cancer is second only to cardiovascular diseases. Although great strides have been made in the treatment of cancer over the past years, it continues to be a major health concern. Therefore, extensive efforts have been devoted to searching for new therapeutic approaches. The growth of new blood vessels (angiogenesis) is one of the well established hallmarks in the process of carcinogenesis. Vascular endothelial growth factor receptor 2 (VEGFR2) plays an essential role in cancer angiogenesis. Where, targeting VEGFR2 will inhibit angiogenesis causing tumor cell death.