Analytical Study in Interactions of Certain Antiviral Drugs

Abstract

The aim of this thesis is to study the interactions between certain antiviral drugs with serum albumin from different sources (bovine and human) and with certain biological matrices such as, human plasma and erythrocytes. Moreover, this thesis includes the development of different simple, sensitive and specific methods for determination of these antiviral drugs; namely ribavirin, sofosbuvir and daclatasvir in pure samples and in biological matrices.

This thesis includes five parts:

Part I: Introduction and literature review This part is divided into two sections:

Section A: General introduction This section comprises data about viral infections specifically, hepatitis C infection, its prevalence in Egypt and treatment. Also, it includes discussing the different forms of drug interactions and the importance of studying drug-plasma protein binding and its significance.