Comparison between Corticosteroids and Antifungal Drugs in Treatment of Allergic Fungal Rhinosinusitis

Abstract

Purpose: The purpose of the study is To compare between steroids' efficacy and antifungal drugs' efficacy in AFRS (Allergic fungal rhinosinusitis) treatment in a Meta-analysis form. As well to find the best treatment protocol in AFRS cases. Patients and Methods: this was a meta-anlysis study comparing diffrent studies regarding efficacy of antifungal drugs and corticostroids in the treatment of AFRS . Results: In this meta-analysis, 3 articles were included with a total number of participants (144) patients and all have been published between 2015 and 2006.The research studies were documented no statistical significant difference between antifungals and steroids in AFRS treatment with Cochran Q = 1.554, df = 1, p-value = 0.213, I-squared = 35.648. (FEM: odds ratio = 0.50, 95% CI (confidence limits) = 0.21 to 1.17, p-value = 0.11) according to Kupferberg grade I-III. In addition, with odds ratio = 0.37, 95% CI = 0.10 to 1.45, p-value = 0.15 according to recurrence. Conclusion: We found in our meta-analysis that there is no difference between using corticosteroids and antifungals in AFRS treatment.