General versus Regional Anesthesia Compared as Maternal and Fetal Outcome in Cases of Toxemia of Pregnancy

Abstract

Abstract • Introduction: Pre-eclamptic toxemia (PET) is a multi-system disorder that is characterized by endothelial cell dysfunction as a consequence of abnormal genetic and immunological mechanisms. Despite active research for years, the exact etiology of this potentially fatal disorder remains unknown. Although understanding of the pathophysiology of preeclampsia has improved, management has not changed significantly over the years. Aim: The aim of the work is to detect the ideal and safest type of anesthesia for both mother and delivered fetus in pre-eclamptic patients undergoing C.S. Patients: A prospective randomized controlled trials was conducted at the department of Anesthesia at Ghamra Military Hospital which is a tertiary hospital in Cairo, Egypt. Eighty seven (n=87) pre-eclamptic parturients undergoing emergency cesarean section were divided in three groups receiving general (G) (n=29): spinal (S) (n=29) or epidural anesthesia (E) (n=29). The study was approved by Research Ethics Committee of Faculty of Medicine, Ain Shams University, Egypt. Patients who attended the hospital, and fulfilled the inclusion criteria were offered to participate in the study after full explanation regarding study design and possibly expected benefits and those who agreed signed a special consent form.