Evaluation of Serum level of thrombomodulin in cases with preeclampsia

Abstract

reeclampsia is a multisystmic disorder of unknown cause. Endothelial cell damage has recently been suggested to underlie the pathologic change in preeclamptic pregnancy. Thrombomodulin an endothelial cell surface glycoprotein act as a co-factor for thrombin catalyzed activation of protein C. activated protein C inhibits coagulation by inactivation the coagulation factor Va and VIIIa. Pre-eclampsia (PE) is a pregnancy specific, multisystem disorder characterized by reduced organ perfusion secondary to diffuse endothelial injury. The condition complicates about 3-6% of pregnancies worldwide. Despite extensive research, the exact etiology of pre-eclampsia remains elusive. Severe preeclampsia is associated with increased risk of maternal mortality (0.2%) and increased rates of maternal morbidity (5%) such as convulsions, pulmonary edema, acute renal or liver failure, liver hemorrhage, disseminated intravascular coagulopathy (DIC), and stroke. These complications are commonly seen in women with preeclampsia that develops before 28 weeks (early onset PE) gestation and in those with preexisting medical conditions.