The effect of intravenous infusion of magnesium sulphate during spinal anesthesia on post-operative analgesia in patients undergoing total hip replacement

Abstract

Total hip replacement arthroplasty is accompanied by moderate to severe pain after surgery and adequate postoperative pain management is important for early rehabilitation and functional recovery. Magnesium (Mg) is the fourth common cation in body. It has antinociceptive effects due to its antagonistic effect of N-methyl-D-aspartate (NMDA) receptor through regulation of Ca influx into cells& can prevent the induction of central sensitization due to peripheral nociceptive stimulation and abolish the hypersensitivity once it is established. We hypothesized that concomitant use of intravenous infusion of magnesium sulfate may have an effect on the block characteristics and duration of action of intrathecal bupivacaine. This study was planned to evaluate and observe the effect of concomitant intravenous infusion of magnesium sulfate in the patients undergoing lower limb orthopedic surgery under subarachnoid block with Bupivacaine on postoperative analgesia This study showed that i.v. magnesium sulphate infusion during surgery under spinal anesthesia reduced postoperative pain and analgesic consumption without any notable complication.