Effect of Usage of the Proton Pump Inhibitor Omeprazole on the Structure of the Kidney of Male Albino Rats

Abstract

Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide. They are used for suppression of gastric acid secretion. The standard clinical indications for treatment with PPIs include gastro esophageal reflux disease (GERD), peptic ulcer disease and erosive esophagitis. PPIs are also prescribed as a prophylaxis against peptic ulcer in combination with some medications like steroids, non-steroidal anti-inflammatory drugs (NSAIDs) and with antibiotics for eradicating Helicobacter pylori (Yadlapati and Kahrilas, 2017). On the other hand, it has been reported that 60% of people on PPIs do not have a verified indication to use the drug. PPIs are even available for sale over the counter without prescription in some countries like the United States (Yadlapati and Kahrilas, 2017).