EFFECT OF SOME ANTIVIRAL SUBSTANCES ON SOME FOOD-BORNE VIRUSES

Abstract

There are some issues with the available antiviral drugs such as drug resistance; also toxicity could be a problem. So the trend was to use the herbal medicine as anti-viral reduce the side effects of antiviral drugs. Moringa is a plant rich in chemicals and elements such as protein, iron, calcium, ascorbic acid vitamin A and antioxidant compounds such as carotenoids, flavonoids, alkaloids, vitamin E and phenolic compounds, so they are useful in medical and nutrition terms, and have recently been used as an antiviral. Coxsackie B virus (COX-BV) and hepatitis A virus (HAV) are the most important foodborne viruses that cause many human diseases. Including insulin-dependent diabetes, myocarditis, meningitis, hepatitis. One of the most important characteristics of these viruses is that the human faeces infected with the virus contains 107 - 1011 virus parts and that the pathogenic dose of the infection usually less than 100 viral parts and that these viruses have high stability in the acid and is resistant to heat, drought, radiation, detergent and environmental stresses. Although these viruses are non-enveloped therefore these viruses are difficult to resist. The aim of this study is to reach some of the substances that have a positive activity of viruses to be used as a treatment for some food-borne viruses and which cause human pathogenic diseases such as viruses COX-BV and HAV. A COX-BV was previously isolated and defined by Seif, et al., (2016), as for HAV was obtained from Holding Company for Biological Product and Vaccines (VACSERA). Propagation of COX-BV and HAV viruses were done in HEP-2 and Vero cells, respectively. These are done by infecting the cells with the viruses in the special flask and then were incubated in the co2 incubator at 37 °C. The cytopathic effects (CPE) of the viruses were monitored daily and the cells were frozen and that wed