The Hemopoietic Stem Cell in Health and Disease

Abstract

The early multi potent stem cells in the lymphohcmopoietic system have extensive proliferative potential, but few differentiated ICatures. They reside brgely in the bone, encased in the bone marrow cavity. These stem cells have the potcnti;d, with appropriate inductive signals, to dillcrenti;!le ;md give rise to popul"tions of progenitor cells. L1rly stem 'cells do not express different linc"gc m;u•kcrs, but they exprcssccrtain . cl"sses of receptor proteins or othc1• m"rkcrs, in hum"'' CD34;md c-kit lwve been propo:;ed "number or disc"ses appc•11• to be of stem cell origin e.g. "plastic ;mcmia, acute mycl(,gcnous lcukcmi;I, mycloclyspl"sia, and paroxysmal noctunwl hemoglobinuria.it is the ••im or this work to highlight the main clwracleristics of the stem cell with study of the pathophisiology in clillcrent disc; scs "J'Jccting it.