Relationship between selenoenzymes and circulating thyroid hormones in chronic renal failure patients

Abstract

Patients with chronic renal failure have a substantially • increased risk to suffer from cardiovascular disease, atherosclerosis, cancer, and aging, compared with age matched individuals from the general population. Also, Serum thyroid hormone concentrations in Patients with chronic renal failure, whether with conservative treatment or with hemodialysis therapy, are usually low, despite normal serum TS!-1. Malondialdehyde, antioxidant substances (vitamin C, vitamin E, selenium), antioxidant enzymes (E-GSHPx and Pl.GSHPx) and thyroid hormones as well as TS!-1 and TBG were measured in 20 non-dialyzed CRF patients(group-I), 47 hemodialyzed patients (group-II) and 20 age matched healthy subjects (control). The results obtained have shown that malondialdehyde was significantly increased in group-I and group-II. Selenium, Pl.GSHPx and vitamin C were significantly decreased in both patient groups. Whereas, E­ GSHPx and vitamin E were not significantly changed. In th meantime, serum thyroid hormones were significantly decreased in both group-I and grqup-If but the TSH and TBG levels were not significantly changed. We can conclude that the non-dialyzed chronic renal failure patients suffer from oxidative stress, which is further exacerbated by hemodialysis. In the same time, we found alterations in the circulating thyroid hormones but without any relationship between altered antioxidants especially selenoenzymes and circulating thyroid hormones.