CHEMICAL AND BIOCHEMICAL STUDIES ON 14C- LABELLED CHLORPYRIFOS j I AND ITS FATE IN COTTON LEAF WORM A THESIS
MOHGA SABRY KHATTAB;
Abstract
A micromethod for the synthesis of the organophosphorus insecticide chlorpyrifos has been established by the reaction of the sodium salt of 3,5,6- trichloro-2-hydroxypyridine with 0,0-diethylthiophosphoryl chloride in dimethylfom1amide.
Following this procedure, Ethoxy-I-'4-c-chlorpyrifos could be synthesized in one-vessel reaction usmg radiolabelled Ethanol-J-14c. The crude radiolabelled product was purified by chromatography on silica gel column using benzene for elution' to produce over 98% radioactively pure
insecticide.
Some of the degradation products of chlorpyrifos were also synthesized. These compounds served as authentic substances for
identification of biotransformation products of the insecticide (Scheme A).
Following this procedure, Ethoxy-I-'4-c-chlorpyrifos could be synthesized in one-vessel reaction usmg radiolabelled Ethanol-J-14c. The crude radiolabelled product was purified by chromatography on silica gel column using benzene for elution' to produce over 98% radioactively pure
insecticide.
Some of the degradation products of chlorpyrifos were also synthesized. These compounds served as authentic substances for
identification of biotransformation products of the insecticide (Scheme A).
Other data
| Title | CHEMICAL AND BIOCHEMICAL STUDIES ON 14C- LABELLED CHLORPYRIFOS j I AND ITS FATE IN COTTON LEAF WORM A THESIS | Other Titles | دراسات كيميائية وكيميائية حيوية على المبيد الحشرى الكلوربيرى فوس المرقم بالكربون المشع ومصيره فى دود ورق لقطن | Authors | MOHGA SABRY KHATTAB | Issue Date | 1998 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B14170.pdf | 954.26 kB | Adobe PDF | View/Open |
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