Epidemiology of fungal infections in neonates correlated with antifungal drug susceptibility testing A Thesis

Abstract

-Nowadays opportunistic fungal infections are a common problem in neonatal intensive care units (NICUs). It appeared to have increased over the past few decades, because there has been an increase in children with primary or secondary immune deficiencies. -Candida species are one of the most common causes of blood stream infections among neonates especially Candida albicans. Also, the study showed that non albicans Candida has emerged as a major cause of neonatal candidemia. -In this study one hundred and seventy six clinical samples suspected of having neonatal bacterial and fungal infections were collected from NICU in Ain Shams Specialized Hospital, Wadi El Nile hospital, and Al Hussein University Hospital. Fifty five cases were positive in blood cultures and PCR, while one hundred and twenty one were negative. These negative cases were excluded from the tested group.