Recent Studies on Multidrug Resistant (MDR) and Extensively Drug Resistant (XDR) Mycobacterium Tuberculosis Complex Isolates from Humans and cows

Abstract

Tuberculosis (TB) is a serious infectious, contagious, airborne, chronic and zoonotic disease, in 2018; 136 years have passed since the discovery of Mycobacterium tuberculosis by Robert Koch as well as 25 years since the WHO declared TB as a global health emergency. The worldwide reemergence of DR-TB strains threaten TB control program; moreover the emergence of drug-resistant M. bovis. Monitoring and tracking TB and DR-TB is a critical component in the management of TB, because it allows the identification of trends, challenges and implemented treatment program successes, in areas that require additional attention.Our study is the first to shed light on genotyping of circulating MDR strains in Egyptian community using Whole Genome Sequencing (WGS). This study revealed that the highest mono-resistance was detected against rifampicin (RIF), there one MDR- M. bovis was detected, and the predominance of Euro-American lineage in Egypt among drug resistance strain.