C - reactive protein versus erythrocyte sedimentation rate in monitoring MDR- tuberculosis

Abstract

TB as a chronic inflammatory disease was commonly associated with significant elevation of inflammatory mediators and cytokines duo to stimulation of liver cells. The acute phase reactants as CRP and ESR reported to be elevated in all kind of inflammation as same as autoimmune disorders. The aim of the current study was using ESR and CRP for mentoring the response of MDR-TB patients toward the treatment protocol, beside evaluation of which one of them was powerful in prediction sputum conversion. A prognostic cohort study was conducted at Abbassia Chest Hospital in a period from March 2018 until the end of November 2018. Twenty-five patients were enrolled in the study, they were diagnosed as MDR-TB by gene expert and sputum culture in LJ media. Patients who were previously diagnosed as MDR/RR-TB with negative smear and those with atypical Mycobacterium tuberculosis were excluded from the study. All the patients were subjected to the followings: medical history including previous treatment history and its duration before being diagnosed as MDR/RR-TB, clinical (general and local) chest examination, chest radiography, sputum evaluation which included direct smear stained by