Evaluation of Anti-biofilm Efficacy of Nano-based Intra-canal Medicaments during Endodontic Retreatment (Randomized Clinical Trial)

Abstract

Nowadays, there is an increasing demand by most of the people to retain their teeth whatever their state. Post treatment endodontic disease is commonly faced by clinicians where they have to clearly understand its causes and how to correctly manage. Failed root canal treatment is mainly due to microbes whether they are persistent or reintroduced ones Understanding the virulence factors of microbes is very important to be able to counteract these factors and increase our clinical success rate. Microbial biofilm is one of the most effective virulence factors produced by different types of microbes and proved to be one of the most common causes of microbial resistance toward different disinfecting agents used during endodontic treatment. Enterococcus faecalis species is one of the most biofilm forming bacteria. Introduction of nanotechnology into different fields of medicine with its well-known antibacterial effect encouraged us to try it in our field of endodontics. This study was done to evaluate the effect of some intracanal medicaments in their nanoform on the bacterial count and their