Incidence of Cytomegalovirus IgG antibodies and the role of Matrix Metalloprotinase-13 (MMP-13)-as a novel tumor marker- for Diagnosis of Breast Cancer in Egyptian Females

Abstract

Breast cancer is the fifth most common cause of cancer death (after lung cancer, stomach cancer, liver cancer, and colon cancer). Breast cancer is the most common invasive cancer in females worldwide. It accounts for 16% of all female cancers and 22.9% of invasive cancers in women. It was estimated that 18.2% of all cancer deaths worldwide, including both males and females, are from breast cancer. MMP-13 known as Collagenase-3 is a member of collagenase subfamily initially identified in breast cancer. It was later found to be over-expressed in other malignant tumors, suggesting that MMP-13 is associated with aggressive tumors. Cytomegalovirus (from the Greek cyto-, "cell", and megalo-, "large") is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Human and monkeys serve as natural hosts. There are currently eight species in this genus including the type species human herpesvirus 5. Diseases associated with HHV-5 include glandular fever, and pneumonia. It is typically abbreviated as CMV. Viruses have been central to modern cancer research and provide profound insight into both infectious and non-infectious cancer causes and players in disease progression.