Impact of Neonatal Cardiovascular Compromise and its Treatment on Brain Electrical Activity and Short-term Clinical Outcome

Abstract

ABSTRACT Background: Amplitude-integrated electroencephalography (aEEG) has been used in clinical research to study the relationship between changes in neonatal cardiovascular function and brain activity. Aim of the Work: To evaluate the impact of cardiovascular compromise on cerebral cortical activity (aEEG measurements) in non-asphyxiated neonates with persistent pulmonary hypertension of newborn (PPHN) or those with shock and hypotension and to identify neonates at risk for neurologic compromise and the relevance of an abnormal aEEG trace to associated hemodynamic changes, therapeutic interventions and short-term clinical outcome measures in these neonates.