Evaluation of hyperbilirubinemia as a predictor of complicated acute appendicitis

Abstract

I n 1886, Reginald H Fitz, a Harvard pathologist, first delineated the clinical condition of acute appendicitis (i.e., inflammation of the vermiform appendix) (Richmond B., 2017). He properly identified the importance of its early diagnosis and timely treatment, as indicated by his analysis of 257 cases of perforating inflammation of the appendix and 209 cases of typhlitis or peri typhlitis (RH, 1886). A couple of years later, Charles McBurney delineated the clinical findings before rupture and advocated early surgical intervention. Despite aggressive intervention, mortality and morbidity remained high through the remainder of the nineteenth century and also the first half of the twentieth century. The mortality related to appendicitis declined with the introduction of antibiotics and with the development of anesthesia and higher perioperative care. Acute appendicitis remains one among the foremost common surgical diseases encountered by physicians.