FORMULATION AND STABILITY OF ANTIBIOTIC IN EYE PREPARTIONS

Abstract

The anatomical structure and the protective physiological process of the eye exert a: strong defense againstocular drug delivety:-This''is' the reason why conventional ocular dosage forms exhibit extremely low bioavailability. Only a small proportion (1-3%) of the applied drug penetrates the cornea and reaches intraocular tissues, so new ocular delivery systems are needed to be developed. In preparation (like Hydrogels, Bioadhesive) ocular bioavailability is increased by increasing the drug residence time in the precorneal area or diminishing side effects due to systemic absorption, thus decreasing the necessary amount of drug for a therapeutic response in the anterior chamber. A proportion of the drug is not available for therapeutic action if the drug applied topically since drug is immediately diluted in the tear film and excess fluid spills over the lid margin and the remainder is rapidly drained into the nasolachrymal duct.