THE HEPATOPROTECTIVE EFFECT OF CASEIN GLYCOMACROPEPTIDE AS COMPARED TO PTEROSTILBENE AND CURCUMIN

Abstract

The use of herbal preparations is getting popular for treating liver fibrosis which is becoming a wide spread disease and there is no safe chemical drug available. Of these herbal plants are the two polyphenols curcumin and pterostilbene which proved to be beneficial for attenuating liver fibrosis. Casein glycomacropeptide (CGMP) is a milk fraction which constitutes about 15-20 % of whey proteins preparations, and proved to have many health benefits. In this work, CGMP which is not a polyphenol, is experimented to find its protective effect on liver at different stages of injury whether at the beginning or after developed fibrosis. Moreover, CGMP was compared with curcumin and pterostilbene on alleviating liver injury. Two experiments were carried out to study the following: 1. To compare between the beneficial effect of feeding CGMP (50 and 100 mg/kg), curcumin (100 mg/kg) and pterostilbene (15 and 40 mg/kg) on liver of rats injected with CCl4. 2. To determine the beneficial effect of feeding CGMP (150 mg/kg) on rats already developed liver fibrosis by their injection with CCl4 for 5 weeks before starting feeding. This was also compared with feeding rats with CGMP (150 mg/kg) coincided with CCl4 injection. CCl4 adversely injured the liver, causing its cells to release their enzymes ALT, AST and ALP, thus increasing their concentration in blood, increasing cells oxidative stress by reducing CAT, SOD and GPx concentration and increasing the concentration of MDA and LDH ,