Therapeutic Effect of Vitamin D3 Supplementation to Clomiphene Citrate Resistant PCOS Women: A Randomized Controlled Trial

Abstract

olycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders affecting females in their reproductive age. Diagnosing PCOS is based on finding two of three criteria according to Rotterdam consensus 2003: oligo/anovulation, hyperandrogenic symptoms, ultrasound finding of polycystic ovary. While insulin resistance (which affects 50 – 70 % of PCOS patients) is considered to be the main reason for hyperandrogenic features, PCOS also leads to various health problems including metabolic disorders (obesity – DM – CVS diseases) in addition to menstrual irregularities and infertility. Recently several studies have investigated the effectiveness of vitamin D in improving metabolic, hyperandrogenic and hormonal profile in PCOS. WHO recommends supplying vitamin D to deficient women, due to its importance for female fertility. Being evidenced that PCOS women have hyovitaminosis D3, we dedicated this work to study therapeutic effect of vitamin D3 supplementation to PCOS women who are resistant to Clomiphene Citrate.