Association of Hydroxy (Steroid) Dehydrogenase 11b1 Gene with Type 2 Diabetes Mellitus in Egyptian Population

Abstract

Type 2 diabetes is a heterogeneous group of metabolic disorders caused by the interaction between genetic predisposition and environmental factors. The incidence of type 2 diabetes mellitus has increased over the last decades with more than 170 million individuals suffering from type 2 diabetes mellitus all over the world which imposes a greater economic impact on individuals, families and health systems. Being a polygenic syndrome, many studies have identified the role of genetic variations related to diabetes and obesity; however the results are still contradictory. This may have occurred due to diversity of the ethnic groups involved and their respective genetic variability as well as variations in the sample size. Furthermore there is divergence regarding diet and lifestyle which modulate the phenotype of body weight. Therefore the present case control study was conducted in order to study the association of hydroxysteroid steroid dehydrogenase 11B1 gene polymorphism with type 2 diabetes mellitus. 100 individuals were included, 60 type 2 diabetic obese individuals and 40 age and sex matched controls. The mean age of individual patients was 50.26 ±9.1 year while the majority of them were females (70%).