Evaluation of Biocidal Activity of Antimicrobial Loaded Nanoparticles Against Staphylococcal Biofilms
Mennat-allah Alaa Mohamed Abd El-fatah;
Abstract
Abstract
Multi-drug resistant and biofilm forming bacteria have surprisingly increased over recent years. On the contrary, the rate of development of new antibiotics to treat these emerging superbugs is very slow. Therefore, aim of the present study was to prepare novel nanobiotic formulations to enhance the antimicrobial activity of the three antibiotics; clindamycin, doxycycline, and linezolid against different species of Staphylococci. Antibiotics were conjugated with nanoemulsions and evaluated for their antimicrobial activities, cytotoxicity, as well as post-antibiotic effects.
Multi-drug resistant and biofilm forming bacteria have surprisingly increased over recent years. On the contrary, the rate of development of new antibiotics to treat these emerging superbugs is very slow. Therefore, aim of the present study was to prepare novel nanobiotic formulations to enhance the antimicrobial activity of the three antibiotics; clindamycin, doxycycline, and linezolid against different species of Staphylococci. Antibiotics were conjugated with nanoemulsions and evaluated for their antimicrobial activities, cytotoxicity, as well as post-antibiotic effects.
Other data
| Title | Evaluation of Biocidal Activity of Antimicrobial Loaded Nanoparticles Against Staphylococcal Biofilms | Other Titles | تقييم النشاط المبيد للأحياء لجسيمات النانو المحملة بمضادات الميكروبات ضد الأغشية الحيوية للبكتيريا العنقودية | Authors | Mennat-allah Alaa Mohamed Abd El-fatah | Issue Date | 2019 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| CC2141.pdf | 409.3 kB | Adobe PDF | View/Open |
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