INSULIN LIKE GROWTH FACTOR-1 AND BINDING PROTEIN 3-TN CHILDREN WITH LIVER DISEASES

Abstract

GH, IGF-1, and IGFBP-3 were studied in 74 children with liver

disease compared to 55 normal children (control). A variable degree of severity and progression of the liver condition was noticed in our patients and according to Child-Pugh score the cases were divided into 2 groups. *Group (I): Children with mild liver disease (Child A)

*Group (II): Children with severe liver disense (Child 13 & C).

Each child was subjected to complete clinical examination and the following investigations were performed: CBC, liver function tests, viral markers (IIBsAg, HCV-ab), hormonal

assay (GH, IGF-1, IGFOP-3) and abdominal ultmsonogmphy.

Group (I) including Children with mild liver disease (Child A) --•- - This group was further subdivided into 2 subgroups according to their ages.

*Subgroup (a): children above 4 years to 9 years

*Subgroup (b): children above 9 years to 13 years.

Group (II) including Children with severe liver disease (Child B & C)

This group was further subdivided into 4 subgroups according to their ages. *Subgroup (a): children from birth to 4 years

*Subgroup (b): children above 4 years to 9 years

*Subgi•oup (c): children above 9 years to 13 years

*Subgroup (d): children above 13 years.

. A positive correlation was established between IGF-1 and age in all groups.