A STUDY OF SERUM LEVELS OF NITRIC OXIDE AND VASOACTIVE INTESTINAL POLYPEPTIDE IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE

Abstract

TJ1e current study was carried out on selected 50 patients wi\h GE�.:(}O males, 20 femalesj-and 10 healthy controls(ri males, ,4,:feip�les). The patientswere divided into five groups- according to (Savary and Miller classification 1984). The.mean" ; . . ! . " .. ,, ' I age. of patients' groups was 39.6±9.8 lyears, their age ranged- I

I from 22-55 years; In the controls.the mean age 28.4±8.3 years/ . '

their age range from 21-50 years. ' . I•

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All members of this study :�er� .subjected to: .history i . • ... . ta�ing, , full clinical and laboratory, investigations including, 1

(CBC, E. .SR. , AST, ALT, T. Billirbin, serum creatinin, blood- urea• nitrogen, T .. cholesterol, LDL,. HDL, TG, urine.sstool j examination, pregnancy test, .and pelvi-abdoiriiiial I ultrasonography, serum NO and VIP levels assay, only for patient's group, upper gastrointestinal endoscopy or 24 hours ambulatory pH monitoring for those with normal upper endoscopy were done.

The results showed that serum NO and VIP levels were significantly higher in GERD patients than in the control group (P<0.05) for each. There was a significant positive correlation between grade of lower end-esophagi tis on one side and serum level of NO ahd VIP on the other side (P < 0.01) for each and

also there was a significant positive correlation between S. VIP

and S. NO (P < 0.05).

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