Relation between Anti-thyroid Peroxidase Antibody and Recurrent Pregnancy Loss: A Case Control Study

Abstract

ABSTRACT Background: Thyroid dysfunction and autoimmunity are relatively common in women of reproductive age group and has been associated with various adverse pregnancy outcomes such as recurrent. The aim of this study was to find out association between anti-tpo antibody and recurrent miscarriage. Patient and Methods: This case control observational study was carried out on 90 pregnant female out which 45 with history of recurrent miscarriage were cases and 45 without such history were controls. Results: The mean age of control group was 25.29 while it was 26.69 in cases group. The prevalence of anti-tpo antibody positivity in the study group was 18.8%.out of 90 pregnant female 17 were positive for anti-tpo antibody. The prevalence of thyroid autoimmunity in pregnant women with recurrent abortion, was (37.8%) while it was (0%) in the healthy group (P=0.0). Conclusion: There was significant relationship between anti thyroid antibody, positivity and recurrent miscarriage.Thyroid autoimmunity can be considered as risk marker for recurrent miscarriage.