Evaluation of Curcumin Gel Compared to Green Tea Gel as an Adjunctive Therapy in Management of Chronic Periodontitis: A Clinical and Biochemical Study

Abstract

eriodontal disease is a common oral disease that is identified by severe inflammation and loss of periodontal attachment apparatus. PPD is one effective mechanical treatment for most periodontal infections and remains an essential part for successful periodontal therapy. The objective of the present study is to compare the clinical efficiency of natural curcumin gel and green tea extract gel as local drug delivery agents in the management of periodontal pockets and to evaluate their release profile and effect on TNF-α concentration in the gingival crevicular fluid (GCF). Periodontal pocket debridement main objectives were to remove the biofilm and calculus present on the root surface. Curcumin enhances wound healing and has a combined anti-inflammatory, antioxidant and antibacterial effect. While green tea has antioxidant, antibacterial and anti-inflammatory effects. The present study entailed forty-two patients having Stage II or III Grade A periodontitis with 42 periodontal pockets ranging from 4 to 6 mm. Patients were divided into 3 groups. Group A was subjected to periodontal pocket debridement followed by application of (2% curcumin gel). Group B was subjected to periodontal pocket debridement followed by application of (12%w/w green tea extract gel). While group C was subjected to periodontal pocket debridement only (control group).