Association between Serum 25-Hydroxyvitamin D Level and Cardiac Functions in Chronic kidney Disease Patients

Abstract

The prevalence of chronic kidney disease (CKD) has increased markedly over past decades due to the aging of the worldwide population. Despite the progress in the prevention and treatment, the cardiovascular (CV) morbidity and mortality remain high among patients with CKD. Altered calcium, phosphorus, parathyroid hormone (PTH), vitamin D levels in chronic kidney disease patients induce mediators of bone-like metabolism and mineralization in the vascular system. Aim of this study was to determine the association between serum 25-hydroxyvitamin D level and the myocardial function ,assessed by tissue Doppler imaging in the CKD population. Our study was conducted on 90 patients with chronic kidney disease classified to three groups according to estimated GFR Group І : 30 CKD patient stage 3,Group 2 : 30 CKD patient stage 4 , Group 3 : 30 CKD patient stage 5,from National institute of nephrology and urology outpatient clinic and inpatient department.