Prevalence of Secretory IgA Deficiency in Salivary Secretions in Patients with Food Allergy

Abstract

ecretory IgA is the principal immunoglobulin on mucosal surface of humans and mammals. Displaying a very different molecular form from the IgA present in the circulation. Operating in a mechanism separating the inside of the body which needs to remain sterile from the outside world rich in antigenic stimuli. Through Immune exclusion and the excretory function of secretory IgA, it blocks microorganisms and toxins from attaching to mucosal target epithelial cells in the GIT, delaying their intrinsic potential to adhere to or penetrate the epithelium. The present study aimedto find a correlation between secretory IgA deficiency and food allergy which aids in understanding the pathogenesis of food allergy. Our study was a randomized case control study that was carried out on 90 children in the pediatric hospital Ain Shams University. Cases enrolled in our study were children of age group from 1 month up to 3 years old who were already diagnosed with food allergy following in the GIT clinic. While Controls are age matched siblings of patients presenting to the outpatient clinic.