Evaluation of E- cadherin and Hydrogen Peroxide in Skin of Patients with Vitiligo
Alaa Abdel-Hakim Abdel-Magid;
Abstract
Vitiligo is acquired depigmentary disorder characterized
by destruction of the epidermal melanocytes leading to the loss
of the skin color.
Oxidative stress has a major role in the aetiopathogenesis
and in melanocytic destruction due to its accumulation in the
melanocytes and the hazardous effects to all compartments of
the cell.
Even in long-lasting disease melanocytes are still present
but these cells have lost their integrity and functionality.
This loss is associated with severe epidermal oxidative
stress caused by the continuous accumulation of H2O2. One
consequence of this H2O2-mediated stress is the oxidation and
deactivation of several important enzymes and proteins in the
epidermal compartment of these patients.
The theory of melanocytorrhagy proposes that NSV is a
primary melanocytorrhagic disorder with altered melanocyte
responses to friction and possibly other types of stress, inducing
their detachment.
The baseline expression of adhesion molecules may
differ in vitiligo patients as compared to controls. The
melanocytes are poorly attached to the basement membrane as
compared to keratinocytes. Melanocytes adhesion, spreading,
by destruction of the epidermal melanocytes leading to the loss
of the skin color.
Oxidative stress has a major role in the aetiopathogenesis
and in melanocytic destruction due to its accumulation in the
melanocytes and the hazardous effects to all compartments of
the cell.
Even in long-lasting disease melanocytes are still present
but these cells have lost their integrity and functionality.
This loss is associated with severe epidermal oxidative
stress caused by the continuous accumulation of H2O2. One
consequence of this H2O2-mediated stress is the oxidation and
deactivation of several important enzymes and proteins in the
epidermal compartment of these patients.
The theory of melanocytorrhagy proposes that NSV is a
primary melanocytorrhagic disorder with altered melanocyte
responses to friction and possibly other types of stress, inducing
their detachment.
The baseline expression of adhesion molecules may
differ in vitiligo patients as compared to controls. The
melanocytes are poorly attached to the basement membrane as
compared to keratinocytes. Melanocytes adhesion, spreading,
Other data
| Title | Evaluation of E- cadherin and Hydrogen Peroxide in Skin of Patients with Vitiligo | Other Titles | تقييم مستوى كادهيرين (E)وبيروكسيد الهيدروجين في جلد مرضى البهاق | Authors | Alaa Abdel-Hakim Abdel-Magid | Issue Date | 2020 |
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