“Possible Cardioprotective Effect of Olive Oil in Experimentally Induced Hyperthyroidism in Rats"
Eman Mohammed Ali Mousa;
Abstract
T
he present study planned to elucidate the cardioprotective effect of olive oil on experimentally induced hyperthyroidism. Isolated hearts from different groups were studied in vitro by the Langendorff heart perfusion assembly in order to investigate intrinsic cardiac functions, cardiac response to β-adrenergic stimulation, as well as the effect of ischemia and reperfusion.
The study was performed on 30 male rats, allocated into 3 groups:
Group I: control group (n=10):
Received i.p injection of the solvent for L-thyroxine, once per day, 6 days/week for successive 4 weeks.
Group II Hyperthyroid group (n=10):
Received i.p. injection of L-thyroxine in a dose of 100μg/kg B.W. once per day, 6 days/week for successive 4 weeks
Group III Olive oil-treated Hyperthyroid group (n=10):
Received i.p. injection of L-Thyroxine as in group II, and by the beginning of the third week of L-Thyroxine administration, co administration of extra virgin olive oil, that was given once daily in a dose of 1ml/100g B.W. by gavage for 2 successive weeks till the end of the study.
he present study planned to elucidate the cardioprotective effect of olive oil on experimentally induced hyperthyroidism. Isolated hearts from different groups were studied in vitro by the Langendorff heart perfusion assembly in order to investigate intrinsic cardiac functions, cardiac response to β-adrenergic stimulation, as well as the effect of ischemia and reperfusion.
The study was performed on 30 male rats, allocated into 3 groups:
Group I: control group (n=10):
Received i.p injection of the solvent for L-thyroxine, once per day, 6 days/week for successive 4 weeks.
Group II Hyperthyroid group (n=10):
Received i.p. injection of L-thyroxine in a dose of 100μg/kg B.W. once per day, 6 days/week for successive 4 weeks
Group III Olive oil-treated Hyperthyroid group (n=10):
Received i.p. injection of L-Thyroxine as in group II, and by the beginning of the third week of L-Thyroxine administration, co administration of extra virgin olive oil, that was given once daily in a dose of 1ml/100g B.W. by gavage for 2 successive weeks till the end of the study.
Other data
| Title | “Possible Cardioprotective Effect of Olive Oil in Experimentally Induced Hyperthyroidism in Rats" | Other Titles | الآثار الوقائية المحتملة لزيت الزيتون علي عضلة القلب في حالات فرط نشاط الغدة الدرقية المستحثة تجريبياً | Authors | Eman Mohammed Ali Mousa | Issue Date | 2020 |
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