Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus

Abstract

ype 2 diabetes mellitus (T2DM) is a heterogeneous group of metabolic disorders usually characterized by the incapability of pancreatic beta (β) cells to increase insulin secretion to compensate for insulin resistance in the peripheral tissues (Alexandra et al., 2017). Type 2 diabetes mellitus (T2DM) represents a global major healthcare burden. According to the International Diabetes Federation (IDF), Egypt is in the World’s ninth place in terms of diabetes incidence, affecting up to 8.9 million people. By the year 2045, Egypt is expected to be in the seventh place, with about 16.9 million diabetic patients, due to the rapidly increasing and aging population, which will be considered one of the highest incidence rates in the Middle East and North Africa region. Therefore, it is crucial to understand the mechanisms that contribute to the pathogenesis of DM (International Diabetes Federation, 2019).