Interaction Of Bupivacine With Ropivacaine for Postoperative Pain Relief

Abstract

Perioperative pain is a potent trigger for the stress response; it activates the autonomic nervous system, and is thought to be an indirect cause of adverse effects on various organ systems. Epidural analgesia is a central neuraxial block technique with many applications (postoperative pain relief and during delivery). Bupivacaine is the most common amide local anesthetic used for epidural analgesia. Ropivacaine is a relatively new amide long acting local anesthetic. Ropivacaine is an effective local anesthetic for epidural anesthesia or analgesia, with lower risk of neuro and cardiac toxicity than bupivacaine. In our study patients was randomly allocated to one of four groups (n=20 each). Group/: general anesthesia and epidural bupivacaine (GB). Group/I: general anesthesia and epidural ropivacaine (GR). Group/II: spinal anesthesia and epidural bupivacaine (SB). Group/V: spinal anesthesia and epidural ropivacaine (SR). There were no significant changes in demographic data, statistically significant (but clinically insignificant) decrease in HR and BP (systolic and diastolic), statistically significant changes in motor power, sensory level, pain score, timing of [st top-up doses of epidural LA and timing of supplemental pethidine (IM). There were no recorded side

• effects (nausea, vomiting, hypotension, syncope, or itching) or complications (hematoma, neurological deficit) between patients of the four groups.