Study the Value of Interleukin-6 As Diagnostic and Predictive marker of Cardiac Events in ST Segment Elevation Myocardial Infarction

Abstract

Inflammatory biomarkers have been shown to be associated with and to predict the onset of cardiovascular events. The predictive value of these markers including interleukin-6 (IL-6) has been demonstrated for subjects with existing coronary artery disease (CAD) and apparently healthy individuals. The aim of this study was to assess the diagnostic value of interleukin-6 compared to troponin I in ST segment elevation MI and to assess the predictive value of elevated interleukin 6 in mortality after ST segment elevation myocardial infarction. This study was carried out on sixty patients presented with STEMI admitted in critical care unit department of Ain Shams university , who were subjected to full history taking including the demographic data, historical data for the present condition, cardiovascular risk factors as smoking, DM, HTN, IHD, other co-morbidities and drug history. Thorough clinical examination was carried out on every case including 12 lead ECG. The following laboratory investigations were also done and include Troponin I, CK-MB, IL-6.