“Effect Of Fucoxanthin On Head And Neck Squamous Cell Carcinoma Cell Line: In Vitro Study“

Abstract

Head and neck cancer constitutes the eighth leading cause of cancer-related deaths worldwide. Its incidence varies widely among different geographical areas: in North America and the European Union, head and neck cancer accounts for 3% to 4% of all cancer diagnosis, while in developing countries its incidence is higher due to smoke and drinking habits in combination with poor socioeconomic status (Siegel et al., 2014). The most common type of head and neck cancer is head and neck squamous cell carcinoma (HNSCC) which is a morbid, frequently lethal disease that affects the epithelial cell lining of the upper aero-digestive tract (UADT, i.e., the oral cavity, pharynx, and larynx) (Leemans et al., 2011). While HNSCC has been strongly associated with tobacco use and heavy alcohol consumption, over the past two decades, high-risk alpha human papillomaviruses (HR α-HPV) have been an important etiological factor for a subset of HNSCC arising from the oropharynx (Gillison et al., 2000).