Nanostructured therapy against bleomycin induced lung fibrosis in male C57BL/6

Abstract

One of the approaches is the use of Nano compounds as a drug carrier because they can provide site specific or targeted drug delivery combined with optimal drug release profiles with minimal cellular side effects. Thus preventing cellular and systemic side effects. This study aims to evaluate the therapeutic effectiveness of loading dexamethasone on Nano chitosan particles as a novel Nano-targeted treatment for bleomycin-induced pulmonary fibrosis in male C57BL/6 mice model. This is achieved with minimal systemic and cellular side effects and effective drug release of dexamethasone to the lung tissue. Dexamethasone loaded on Nano chitosan treatment was further compared with the widely used treatment dexamethasone either alone or combined with the improved form of curcumin which is Nano curcumin. Nano chitosan (NCH) particles were chemically analyzed by scaning electron microscope (SEM) Transmission electron microscope (TEM), Energy dispersive X-ray analysis (EDXA) and Fourier transform infrared spectroscopy (FTIR). These chemical analysis were carried out for Nano-chitosan particles before and after loading with dexamethasone. Chemical characterization of the novel synthesized nano particle confirmed that dexamethasone was effectively loaded onto NCH-particles. Chemical Characterizations