Efficacy and Release Profile of Subgingivally Delivered Simvastatin Utilizing In Situ forming Implant as an Adjunctive in Treatment of Severe Chronic Periodontitis (A Randomized Controlled Clinical Trial)

Abstract

Periodontitis can be defines as “An infectious disease resulting in inflammation within the supporting tissues of the teeth, progressive attachment, and bone loss. It is characterized by pocket formation and/or gingival recession.”

Periodontal treatment should result in inflammation elimination, stop periodontal disease progression, enhance esthetics and produce an environment which is useful to maintain periodontal health. Firstly, non surgical periodontal therapy (NSPT) is the keystone of periodontal treatment and the primary approach suggested for the management of periodontal infections.

Pharmacotherapeutics may have an adjunctive role in the management of periodontitis either to slow the progression of the diseases or to improve periodontal status in certain patients. Local application into periodontal pocket could be very advantageous, both in terms of rising drug concentration directly in the action site, preventing systemic side effects, and facilitating prolonged and controlled drug delivery to improve clinical signs of periodontitis.

In the present study two different forms of drug delivery system were utilized. The first delivery system is the in situ implant system which is an Injectable liquid preparation that is