Serum level of Nerve Growth Factor in Autistic Children: Relation to Autoimmunity and Serum Serotonin level
Mahmoud Maher Mahmoud;
Abstract
his study aimed to investigate the relationship between serum levels of nerve growth factor and both hyperserotonemia and the frequency of serum anti-myelin basic protein auto-antibodies in autistic children.
Serum levels of nerve growth factor, serum serotonin and serum anti-myelin basic protein auto-antibodies were investigated in 22 autistic children (17 males and 5 females). Their ages ranged between 3 and 11 years (mean ± SD = 5.41 ± 2.14 years) in comparison to 22 healthy age- and sex-matched healthy control children (16 males and 6 females). Their ages ranged between 3 and 11.5 years (mean ± SD = 6.09 ± 2.20 years).
The degree of the disease severity was assessed by using CARS and according to this scale, children who have scored 30–36 have mild to moderate autism (n =16),while those with scores ranging between 37 and 60 points have a severe degree of autism (n=6).
A family history of autoimmune diseases was significantly higher in children with autism (54.5%) than healthy control children (18.2%), P<0.05.
Although the frequency of allergic manifestations in families of children with autism (22.7%) was higher than
Serum levels of nerve growth factor, serum serotonin and serum anti-myelin basic protein auto-antibodies were investigated in 22 autistic children (17 males and 5 females). Their ages ranged between 3 and 11 years (mean ± SD = 5.41 ± 2.14 years) in comparison to 22 healthy age- and sex-matched healthy control children (16 males and 6 females). Their ages ranged between 3 and 11.5 years (mean ± SD = 6.09 ± 2.20 years).
The degree of the disease severity was assessed by using CARS and according to this scale, children who have scored 30–36 have mild to moderate autism (n =16),while those with scores ranging between 37 and 60 points have a severe degree of autism (n=6).
A family history of autoimmune diseases was significantly higher in children with autism (54.5%) than healthy control children (18.2%), P<0.05.
Although the frequency of allergic manifestations in families of children with autism (22.7%) was higher than
Other data
| Title | Serum level of Nerve Growth Factor in Autistic Children: Relation to Autoimmunity and Serum Serotonin level | Other Titles | العلاقة بين مستويات عامل النمو العصبي في مصل الأطفال المصابين بالتوحد وإختلال المناعه الذاتيه ونسبة السيروتونين فى المصل | Authors | Mahmoud Maher Mahmoud | Issue Date | 2020 |
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