Utilization of nanocomposites and nanoparticles as osteogenic and bone mineralizing biomaterials in osteoporotic rat model
Enas Ahmed Fouad Mohamed El Hady Youssef;
Abstract
The current investigation goaled to assess the efficacy of nanohydroxyapatite (nHA), chitosan/hydroxyapatite nanocomposites (nCh/HA) and silver/hydroxyapatite nanoparticle (nAg/HA) in reconstruction of bone in osteoporotic rat model induced by ovariectomy.
The characterisation of the manufactured nanomaterials (nHA, nCh/HA and nAg/HA) by TEM and SEM approved their nanoscale with rod-shape.
The PDI values extracted from zeta potential and size distribution measurements illustrated the present nanomaterials as highly polydisperse. Zeta potential measurements provided an indication of the predominance of nHA in the nCh/HA nanocomposite and denoted silver substitutions for calcium into the hydroxyapatite lattice.
FT-IR curves formed at the appropriate wavelength specifies that the formed nHA does not possess any impurities and proves the incorporation of chitosan or silver within nCh/HA or nAg/HA composites.
The XRD peaks matched well the data for standard hydroxyapatite phase. All in all, the general characterisation of the tested nanomaterials elucidates the absence of impurities
and establishes the incorporation of chitosan or silver within
The characterisation of the manufactured nanomaterials (nHA, nCh/HA and nAg/HA) by TEM and SEM approved their nanoscale with rod-shape.
The PDI values extracted from zeta potential and size distribution measurements illustrated the present nanomaterials as highly polydisperse. Zeta potential measurements provided an indication of the predominance of nHA in the nCh/HA nanocomposite and denoted silver substitutions for calcium into the hydroxyapatite lattice.
FT-IR curves formed at the appropriate wavelength specifies that the formed nHA does not possess any impurities and proves the incorporation of chitosan or silver within nCh/HA or nAg/HA composites.
The XRD peaks matched well the data for standard hydroxyapatite phase. All in all, the general characterisation of the tested nanomaterials elucidates the absence of impurities
and establishes the incorporation of chitosan or silver within
Other data
| Title | Utilization of nanocomposites and nanoparticles as osteogenic and bone mineralizing biomaterials in osteoporotic rat model | Other Titles | إستخدام تركيبات و جسيمات نانوية كمواد حيوية لتكوين و تمعدن العظام لنموذج هشاشة العظام فى الجرذان | Authors | Enas Ahmed Fouad Mohamed El Hady Youssef | Issue Date | 2020 |
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