Evaluation of the role of microRNAs as regulators of Cytochrome P450 genes in pyrethroid-resistant Culex pipiens mosquito (Diptera: Culicidae)

Abstract

Mosquito vectors transmit wide variety of pathogens that cause severe human illness. The currently applied vector control programs are mostly depending on using pyrethroid insecticides. The intensive exposure of mosquito vector to pyrethroid insecticides has led to arising of pyrethroid resistant population. Resistance in Cx. pipiens mosquitoes was documented as a global problem. Monitoring and measuring the development of resistance in Cx. pipiens populations to pyrethroid is of paramount for vector control management. Hence the present study shed light on understanding insecticide resistance mechanisms.

In the present study, Culex pipiens mosquito larvae were collected from breeding sites in Mansourya canal, Giza governorate, Egypt. Laboratory susceptible Cx. pipiens population was used as a control in the toxicology, biochemical and molecular genomics assays.