Study of Protective Roles of Some Techniques in Ischemia Reperfusion Injury in the Liver of Male Rats

Abstract

The present study was planned to investigate the effect of ischemia reperfusion (IR) injury in liver and to compare between different techniques designed to mitigate the impact of hepatic IR injury. The study compares the effect of topical hypothermia (TH), ischemic preconditioning (IPC) and mitoquinone (MitoQ) pretreatment on changes in hepatic performance due to IR injury. Also, this study investigated the mechanism of action and level of protection provided by the studied strategies against hepatic IR injury which may aid in deciding the most protective approach for clinical application. The study was performed on 67 adult male albino rats, divided into the following groups Group I: sham control group • Rats were subjected to sham operation where a midline incision was done for 45 minutes and then the wound was closed for 90 minutes.