Role of Hepcidin as a biomarker for iron status in patients on regular hemodialysis after treatment of hepatitis C virus

Abstract

ESRD can be defined as the final stage of chronic renal failure where there is a progressive, irreversible deterioration in renal function which the body’s ability to maintain metabolic and fluid and electrolyte balance fails, resulting in uremia. Although ESRD has many causes that vary from one patient to another, the most common causes are hypertensive nephropathy and diabetic nephropathy. Management of ESRD includes RRT by heamodialysis, heamofiltration, heamodiafiltration, slow continuous ultrafiltration, or peritoneal dialysis. For patients on chronic RRT, renal transplantation offers improved survival, better quality of life. Anemia commonly occurs with chronic kidney disease (CKD). It might begin to develop in the early stages of CKD and tends to worsen as CKD progresses in which anemia occurs in the majority of patients with ESRD who require dialysis therapy. The primary cause of anemia in chronic kidney disease is erythropoietin deficiency as diseased or damaged kidneys can’t produce enough EPO which prompts the bone marrow to make red blood cells, which then carry oxygen throughout the body. As a result, the bone marrow makes fewer red blood cells, causing anemia.