Propofol Versus Midazolam : Safety and Efficacy For Sedating Patients Undergoing Endoscopic Retrograde Cholangiopancreatography ERCP

Abstract

Our study was done in Assiut university hospital at GIT Endoscopy unit between 1999-2000 to evaluate the efficacy, safety and physiological responses with sedation of propofol and midazolam in patients undergoing ERCP. Forty adult patients aged from 30 to 70 years old admitted for routine diagnostic and therapeutic ERCP were allocated randomly into two groups:

Group (I) : Propofol group (n.=20) received a subhypnotic bolus dose ofprpofol 0.6 mg/kg iv over 10 seconds.

Group (11): Midazolam group (n.=20) received a subhypnotic bolus dose of midazolam O .. 06 mg/kg iv over IO seconds. This was followed by repeated doses of 50% of the initial dose in both groups as required.

Before the procedure, all patients were instructed in how to use 100 mm. visual analogue scale (VAS) which consists typically of 10 cm. horizontal line bounded by "no difficulty" on the left end and "maximum possible difficulty" on the right end. Patients indicate their discomfort intensity on 1-10 scale (Carlsson and Grattidge, 1995) .

. All patients received supplemental oxygen 2 L/min. via a nasal cannula raised to 5 L/min. if oxygen saturation decreased below 90%.

Oxygen saturation and heart rate were continuously recorded by pulse oximetry. Non invasive arterial blood pressure was recorded at 10 min. interval through a Dinamap. Breathing was observed for

evidence of any abnormal breathing patterns and calculation of the